Product Code: 25EL-509-4035
Please note: This is a Single Viewer registration for one participant for the on-demand version of this program. Access instructions for the on-demand version of this program will be provided via email approximately 3-10 business days after the live program has occurred and the on-demand version is available. If registering after the on-demand version is available, immediate access is granted via the AABB Education Platform at https://education.aabb.org.
If you registered for the live program you do not need to register for this on-demand eCast (access to the on-demand eCast was included with the live program registration).
If you are interested in presenting this program to a group, please see the “eCast Registration Form– Group Viewing” form on the program page.
Program Description: This program explores the Duffy (FY) blood group system antigens and related antibodies using a lecture format with accompanying complex serologic case studies. Beginning with an overview of the structure and physiologic role of the FY glycoprotein, ACKR1 (Atypical Chemokine Receptor 1), this program will describe the significance of this glycoprotein as a ligand for malarial parasites and the effect on natural selection for the Fy(a-b-) phenotype. The molecular basis of FY blood system antigens along with genetic variations that affect FY blood group system antigen expression will be described. Furthermore, the link between Fy(a-b-) red blood cell phenotype and Duffy-null Associated Neutrophil Count (DANC) will be examined highlighting the critical role of the transfusion service laboratory in confirming the diagnosis to ensure appropriate clinical management. Finally, this program will review the clinical significance of antibodies directed against FY blood group system antigens and utilize case studies to illustrate approaches to identify these antibodies in the transfusion service laboratory.
