Product Code: 25EL-509-2035
Please note: This is a Single Viewer eCast registration for one participant for this eCast for both the live and on-demand version of this eCast. If you are interested in presenting this program to a group, please see the “eCast Registration Form– Group Viewing” form on the eCast program page.
Access instructions for the live eCast will be provided via email approximately 2-3 business days prior to the live program date. Access instructions for the on-demand version of this program will be provided via email approximately 3-10 business days after the live program has occurred and the on-demand version is available.
Program Description: This program explores the Duffy (FY) blood group system antigens and related antibodies using a lecture format with accompanying complex serologic case studies. Beginning with an overview of the structure and physiologic role of the FY glycoprotein, ACKR1 (Atypical Chemokine Receptor 1), this program will describe the significance of this glycoprotein as a ligand for malarial parasites and the effect on natural selection for the Fy(a-b-) phenotype. The molecular basis of FY blood system antigens along with genetic variations that affect FY blood group system antigen expression will be described. Furthermore, the link between Fy(a-b-) red blood cell phenotype and Duffy-null Associated Neutrophil Count (DANC) will be examined highlighting the critical role of the transfusion service laboratory in confirming the diagnosis to ensure appropriate clinical management. Finally, this program will review the clinical significance of antibodies directed against FY blood group system antigens and utilize case studies to illustrate approaches to identify these antibodies in the transfusion service laboratory.
