Scientific Research Grant Award Recipients

Tessa Barrett, BSc (Hons), PhD
NYU Grossman School of Medicine
Project Title: “Perioperative Bleeding: Study of Novel Platelet Candidates and a Diagnostic Transcriptomic Signature”
Project Summary: Perioperative bleeding is a common complication during surgery and is associated with morbidity and mortality. There are unknown mechanisms predisposing individuals to pathologic bleeding, and perioperative bleeding risk scores are limited in predictive utility. The goal of this proposal is to 1) uncover novel pathways that regulate hemostasis and 2) develop a diagnostic tool to identify individuals at increased risk of perioperative bleeding.

Elliott J. Hagedorn, PhD
Boston University and Boston Medical Center
Project Title: “Stabilin Scavenger Receptors and the Trans-endothelial Migration of Blood Stem Cells”
Project Summary: Our research leverages unique tools in zebrafish to define the specific molecular mechanisms that determine whether a circulating hematopoietic stem cell (HSC) migrates across the blood vessel wall and into its bone marrow niche - a critical step for successful HSC transplantation. Unlike mammals, zebrafish are transparent, which allows us to directly visualize HSCs in a live animal while simultaneously using chemical and genetic manipulation to mechanistically elucidate the underlying biology.

Shang-Chuen Wu, PhD
Brigham and Women’s Hospital Harvard Medical School
Project Title: “Innate Drivers of Adaptive Immune Responses Relevant to Transfusion Medicine”
Project Summary: Blood group positive microbes drive the formation of anti-blood group antibodies capable of causing ABO(H) incompatible hemolytic transfusion reactions (HTRs). Our results also demonstrate that a series of innate immune lectins called galectins possess the ability to specifically bind and kill blood group positive microbes through engagement of their blood group antigens, which shapes the specificity and clinical significance of naturally occurring anti-ABO(H) blood group antibodies.

Erika Marques de Menezes, PhD
Vitalant Research Institute
Project Title: “Do Extracellular Vesicles Derived from Cold-Stored Platelets Act as Pro-inflammatory Mediators?”
Project Summary: Despite strong evidence supporting an association between platelet storage lesions and metabolic changes, the main mechanisms underlying the association are not well defined. Studies in this proposal will bring cutting-edge, high-throughput testing platforms for characterizing extracellular vesicles and their cargo to reveal a novel measure of inflammatory response for discovering predictors of a platelet storage lesion and elucidate new pathways that could be harnessed to provide more targeted therapies.

Julia Z. Xu, MD, MScGH
University of Pittsburgh
Project Title: “Effect of Transfusion Modality on Hemorheology and Vascular Function in Sickle Cell Disease”
Project Summary: Anemia is a hallmark of sickle cell disease (SCD) and a major driver of patient morbidity. However, correction of anemia requires careful balancing of raising blood viscosity and microvascular oxygen delivery. Simple transfusion is frequently used to treat severe anemia in SCD, but exchange transfusion may offer more hemorheological benefit. Here, we will compare the effects of simple versus exchange transfusion on mechanisms driving microvascular perfusion and function in patients with SCD.

Patricia E. Zerra, MD
Emory University
Project Title: “Mechanisms Underlying Factor Viii-specific CD4 T Cell Activation in Mice With Hemophilia A”
Project Summary: Antibodies against factor VIII (inhibitors) are a major complication in the treatment of hemophilia, with no current therapies to prevent their formation. We have identified marginal zone (MZ) B cells as a key initiating immune population in inhibitor development. Our research aims to determine mechanisms by which MZ B cells contribute to propagation of the immune response to factor VIII, with the ultimate goal to develop approaches to prophylactically predict and prevent inhibitor development.

Susan R. Conway, MD
Children's Research Institute
“Harnessing the naïve T-cell compartment to generate multi-antigen-specific SARS-CoV-2-specific T-cells”

Mark N. Lee, MD, PhD
Dana-Farber Cancer Institute
“Identification of T cell epitopes in hemophilia patients with inhibitors using next-generation mapping technologies”

Yunfeng Liu, PhD
New York Blood Center
“Mechanisms of interferon activation and mononuclear phagocyte expansion in sickle cell disease”

Mara Pavel-Dinu, PhD
Stanford University
“Discovery of mechanisms supporting the long-term regenerative potential of CRISPR/Cas9 – AAV6 genome targeted human hematopoietic stem cells”

W. Alton Russell, MS, PhD
The Royal Institution for the Advancement of Learning/McGill University
“Tailoring blood donation intervals to individual risk in South Africa, the Netherlands, and the United States”

Liang Zheng, PhD
University of Kansas Medical Center Research Institute, Inc.
“Ankrd26, Thrombocytopenia 2 and TTP”

Annamaria Aprile, PhD
Ospedale San Raffaele
"Exploring the role of FGF23 in β-thalassemia: a novel target to ameliorate bone marrow microenvironment and anemia"

Agnieszka Czechowicz, MD, PhD
Stanford University
"Determine genetic factors and mutations that regulate progression to bone marrow failure and myeloid neoplasia in Fanconi anemia"

Areum Han, PhD
Boston Children’s Hospital
"The role of the RNA editor-exonuclease axis in RNA turnover during erythropoiesis: from mouse embryo studies to in vitro modeling"

Robert H. Lee, PhD
University of North Carolina
"Efficacy of platelet transfusion in the setting of anti-platelet therapy"

Larry Luchsinger, PhD
New York Blood Center
"Caveolae Coordination of Signal Transduction Pathways in Hematopoietic Stem Cell Function"

Evan Orenstein, MD
Emory University
"Improving Patient Blood Management in Pediatrics through Automated Medical Error Detection and Clinical Decision Support Design"

David Roh, MD
Columbia University
"Red Blood Cell Contribution to Coagulopathy and Cerebral Oxygenation after Intracerebral Hemorrhage"

Kim Vanuytsel, PhD
Boston Medical Center
"Validation of a potential curative gene editing approach across the diverse sickle cell disease (SCD) patient population using induced pluripotent stem cells (iPSC)”

Alma-Martina Cepika, MD, PhD
Leland Stanford Junior University
“Personalized Tr1 Cell-Based Therapy for Graft-vs-Host Disease”

Simon J. Cleary, PhD
University of California, San Francisco
“New Approaches to Study and Treat Alloantibody-Mediated Diseases Resulting from Blood Transfusions”

Pietro Genovese, BSc, MSc, PhD
Dana-Farber Cancer Institute
“Engineering Immunotherapy Resistant Hematopoiesis to Treat High-Risk Acute Myeloid Leukemia”

Panagiotis Mistriotis, PhD
Auburn University
“Eliminating Senescent Bone Marrow-Derived Mesenchymal Stem Cells Using Microfluidics”

Jansen N. Seheult, MB BCh BAO, MSc, MS, MD
University of Pittsburgh School of Medicine
“A Stochastic, Multicompartment, Dynamic Model of Hemostasis and Oxygenation During Trauma Resuscitation: Building a Platform for in Silico Trials of Transfusion Strategies”

Delfim Duarte, MD, PhD
Instituto de Biologia Molecular e Celular (IBMC)
"Targeting the Bone Marrow Vascular Microenvironment to Improve Hematopoietic Stem Cell Therapies in Acute Myeloid Leukemia"

Saba Ghassemi, PhD
University of Pennsylvania
"Redirecting Quiescent T cells with Chimeric Antigen Receptors (CARs) for Adoptive Immunotherapy"

Marie Hollenhorst, MD, PhD
Stanford University
"CMP-Neu5Ac: A Central Molecule in Bleeding Diseases and Mediator of a Novel Platelet Effector Function"

Tiffany Thomas, PhD
Columbia University Medical Center
"The Effect of Dietary Lipids on Red Cell Lifespan and Recovery"

Francesca Vinchi, PhD
New York Blood Center
"Role of Heme-Activated Macrophages in Acute Chest Syndrome"

Yan Zheng, MD, PhD
St. Jude Children's Hospital
"Comprehensive Characterization of RH Loci by Whole Genome Sequencing and Long-read Genome Sequencing"

Arunoday K. Bhan, PhD
Boston Children's Hospital
“Identifying megakaryocyte maturation pathways critical for platelet generation.”

Vijay G. Bhoj, MD, PhD
University of Pennsylvania
“Dissecting the Humoral Response to FVIII for Therapeutic Applications.”

Avital Mendelson, PhD
Lindsley F. Kimball Research Institute
New York Blood Center
“A biomimetic niche for platelet formation in vitro.”

Antonella Nai, BSc, MSc, PhD
Ospedale San Raffaele, Italy
“Targeting the second transferrin receptor for amelioration of severe malarial anemia.”

Robert S. Nickel, MD, MSc
Children's Research Institute
“Hydroxyurea and Transfusion (HAT): Pilot Study of Combination Therapy for Patients with Sickle Cell Anemia.”

Hideyuki Oguro, PhD, MSc, BSc
The Jackson Laboratory
“Induction of hematopoietic stem cell proliferation and mobilization by estrogen receptor signaling.”

Moritz Stolla, MD, PhD
Bloodworks Northwest Research Institute
“Cold-stored Platelets for the Reversal of Dual Antiplatelet Therapy.”

Benjamin Samelson-Jones, MD, PhD
Children’s Hospital of Philadelphia
“Novel Therapeutics for Hemophilia B: A Rational Pursuit of Bioengineered Factor IX Variants with Enhanced Clotting Activity”

Juliana Xavier-Ferrucio, PhD
Yale University
“Megakaryocyte erythroid progenitor fate specification under iron and oxygen deficiency”

Angelo D’Alessandro, PhD
University of Colorado Denver – Anschutz Medical Campus
“The role of adenosine signaling in the preservation of energy metabolism of stored erythrocytes”

David Gibb, MD, PhD
Yale University School of Medicine
“Characterizing innate immune mechanisms underlying the link between inflammation and RBC alloimmunization”

Mobin Karimi, MD, PhD
University of Pennsylvania
“Separation of GVHD from GVT responses by modulation of T cell signaling pathways”

Troy Lund, MD, PhD
University of Minnesota
“Adipokine Regulation of Hematopoietic Cell Homing”

Sandhya Panch, MBBS, PPH
National Institutes of Health
“Barcoded macaque transplants: A novel approach to study Human Umbilical Vein Endothelial Cell (HUVEC) expanded hematopoietic stem and progenitor cell (HSPC) engraftment and repopulation kinetics”

James Ankrum, PhD
The University of Iowa
“Elucidating the role of FOXO3 in restoring the potency of in vitro expanded mesenchymal stem cells.”

Yacine Boulaftali, PhD
Inserm, U1148- Laboratory for Vascular Translational Science (LVTS), France
“Neutralizing serpinE2: a new medical concept of treating haemophilia.”

Lindsey A. George, MD

University of Pennsylvania, Perelman School of Medicine
“Prothrombin activation in vivo: contribution of membrane binding for effective hemostasis and development of a novel warfarin reversal strategy.”

Sarika Saraswati, PhD
Vanderbilt University
“New Strategies to Augment Efficacy of Stem Cell Therapy for Therapeutic Revascularization”.

William Savage, MD, PhD
Brigham and Women’s Hospital
“Aeroallergen-specific antibodies in allergic transfusion reactions.”

Ramesh Nayak, PhD
Hoxworth Blood Center (HBC), Cincinnati Children’s Hospital Medical Center (CCHMC) 
“Angiotensin in stem cell recruitment and mobilization”

Richard Francis, MD, PhD
Columbia University Medical Center
“Effect of glucose-6-phosphate dehydrogenase deficiency on red blood cell storage”

Neil Hanchard, MD, PhD
Baylor College of Medicine
“A genomics approach to transfusion responders in sickle cell disease”

Krystalyn Hudson, PhD
Bloodworks Northwest Research Institute
“Establishment and maintenance of lymphocyte tolerance to red blood cell antigens”

Julie Peterson, PhD
Blood Research Institute, BloodCenter of Wisconsin
“Recombinant glycoprotein fragments for improved detection of alloantibodies in Neonatal Alloimmune Thrombocytopenia (NAIT)”

Claude Tayou Tagny, MD, MS, MSc
University of Yaoundé, Cameroon
“Risk Factors of HIV infection in Sub-Saharan Africa blood donor – A pilot phase in Cameroon”

Stella T. Chou, MD
University of Pennsylvania, Perelman School of Medicine
“Red blood cell generation from human induced pluripotent stem cells: a new tool for transfusion medicine”

William Janssen, MD
National Jewish Health, University of Colorado Denver
“Degradation of the Pulmonary Endothelial Glycocalyx in Transfusion Related Acute Lung Injury (TRALI)”

George J. Murphy, PhD
Center for Regenerative Medicine (CReM)
“Pluripotent stem cells in the modeling of blood disease and the development of potentially transfusable human red blood cells and platelets”

Robert B. Neuman, MD
Emory University School of Medicine
“Physiologic effects of RBC storage in chronic transfusion recipients: vasoreactivity, exercise capacity, and oxygen consumption”

Sean Stowell, MD, PhD
Emory University School of Medicine
“Characterization of Immunity and Tolerance Following RBC Transfusion”

Stephanie Eisenbarth, MD, PhD
Yale University, Laboratory Medicine and Internal Medicine
“Identifying Innate Immune System Pathways Critical for RBC Alloimmunization”

Anand Padmanabhan, MD, PhD
BloodCenter of Wisconsin
“Role of IgA and IgM Immunoglobulins in Heparin-Induced Thrombocytopenia and Thrombosis (HIT)”

Tracey L. Papenfuss, DVM, MS, PhD
Ohio State University, Waxner Medical Center, Regenerative Medicine
“Development of myeloid derived suppressor cell therapy for the treatment of inflammatory disease”

Michael Nemeth, PhD
Roswell Park Cancer Institute
“Improving Bone Marrow Transplantation Through Targeting Hematopoietic Stem Cell Quiescence”

Henrique Viega-Fernandes, DVM, PhD
Instituto de Medicina Molecular (IMM), Portugal
“Modulation of RET Signaling in Hematopoietic Stem Cell Transplantation”

Jianhua Yu, PhD
The Ohio State University
“Preclinical Studies of the Combination of Recombinant Human FLT3 Ligand and AMD3100 to Mobilize Allogeneic Blood Cell Grafts for Transplantation”

Attilio Bondanza, MD, PhD
H San Raffaele, Italy
“Cell Therapy of Multiple Myeloma by Genetic Redirection of T Cells Against CD44v6”

Mettine H.A. Bos, PhD
Leiden University Medical, Netherlands
“Mechanisms Regulating the Macromolecular Enzyme Complex Assembly in Blood Coagulation”

Swapan Kumar Dasgupta, PhD
Baylor College of Medicine
“Signaling Cascade Leading to Phosphatidylserine Exposure in Stored Platelets”

Eldad Hod, MD
Columbia University Medical Center
“Effect of Repeat Blood Donation on Atherosclerosis and Cancer Risk in Murine Models”

Katherine MacNamara, PhD
Albany Medical College
“IFNγ-Mediated Control of Hematopoietic Stem and Progenitor Cell Differentiation”

Nilam Mangalmurti, MD
University of Pennsylvania
“Role of Red Cell Advanced Glycation End products in Endothelial Dysfunction”

Julie Audet, PhD
University of Toronto, Canada
“Directed Expansion and Differentiation of Blood Progenitor Cells using TAT-Conjugated Transcription Factors”

Rachel Bercovitz, MD
The University of Colorado, Denver
“Transfusion-related Acute Lung Injury (TRALI) from Plasma Products: Understanding the Pathogenesis of Immune- and Non-Immune-Mediated TRALI and Determining Methods to Mitigate TRALI Risk”

Jonathan Finn, PhD
Children's Hospital of Philadelphia
“The Development and Safety Characterization of Novel Hyper-functional Factor IX Variants for the Treatment of Hemophilia B”

Peter Ghoroghchian, MD, PhD
University of Pennsylvania
“Fundamental Design and Characterization of Nanoscale Polymersomes as Advanced Hemoglobin-based Oxygen Carriers”

Mariluz Mojica Henshaw, PhD
University of Utah
“Development of a Xeno-free Microcarrier-based Human Mesenchymal Stem Cell Expansion System”

Jill Johnsen, MD
Puget Sound Blood Center
“The Role of Blood Group Antigens in Von Willebrand Factor Homeostasis”

Bartolomeu Nascimento, MD
Sunnybrook Health Sciences Centre, Toronto
“Trauma Resuscitation Formula-driven versus Laboratory-guided Transfusion Study (TRFL): Coagulopathy Substudy”

Alicia Barcena, PhD
University of California San Francisco
“Evaluation of human fetal membranes as a source of hematopoietic stem cells.”

Daniel Gonzalez-Nieto, PhD
Cincinnati Children's Hospital Medical Center
“Connexin-43 in the hematopoietic stem cell niche.”

Taku Kambayashi, MD, PhD
University of Pennsylvania
“The role of GMCSF in regulatory T-cell proliferation and homeostasis.”

Chance John Luckey, MD, PhD
Brigham and Women's Hospital Blood Bank
“Directed differentiation of embryonic stem cells by regulated caspase9 cleavage of zona-occludens2.”

Nicolas Pineault, PhD
Héma-Québec, Canada
“A cellular-based therapy to prevent or reduce thrombocytopenia.”

Ayaz Rahman, MD
Emory University
“The effects of fresh versus older RBC transfusions in subjects with cardiovascular disease.”

Rahima Zennadi, PhD
Duke University Medical Center
“Regulation by nitric oxide of sickle red cell adhesion.”

Hava Avraham, PhD
Harvard Institute of Medicine, Beth Israel Deaconess Medical Center
“Hematopoietic Stem Cell Mobilization by Cannabinoids”

Rose Beck, MD, PhD
Case Western Reserve University School of Medicine
“Notch-induced NK Cells for Cell Therapy in Hematologic Maligancy”

Christine M. Cserti-Gazdewich, MD, FRCP
University of Toronto, Canada
“Cytoadherence in Pediatric Malaria (CPM) Study.”

Nobuharu Fujii, MD, PhD
Fred Hutchinson Cancer Research Center
“Identification of Novel H-Y Antigens using Artificial Neural Network”

Mark R. Looney, MD
University of California, San Francisco
“The Role of Platelets in Experimental Transfusion-related Acute Lung Injury (TRALI)”

Adam Munday, MD PhD
Puget Sound Blood Center
“Platelet Cold Receptors: Potential for Improving Platelet for Improving Cold Storage”

Beth Shaz, MD
Emory Center for Transfusion and Cellular Therapies, Emory University School of Medicine
“Blood Donation considerations in African Americans”

Spero Cataland, MD
The Ohio State University
“A Randomized Study of Concurrent Cyclosporine and Plasma Exchange versus Concurrent Corticosteroids and Plasma Exchange as the Initial Therapy of Thrombotic Throbocytopenic Purpura”

Peiman Hematti, MD
University of Wisconsin-Madison
“ESC-derived MSC transplantation in NOD/SCID mice”

Cheryl Ann Lobo, PhD
New York Blood Center
“Role of Red Cell Glycophorins in the Invasion of Babesia divergens”

A. Louise McCormick, PhD
Emory University School of Medicine
“The role of cytomegalovirus-encoded inhibitor of caspase-8 activation, vICA, in disease following transfusion or transplantation”

Michael Milson, PhD
Cincinnati Children's Hospital Medical Center
“Genetic correction of the Fanconi Anemia stem cell defect”

Lirong Qu, MD, PhD
University of Pittsburgh
“Detection and Quantification of Human Herpesvirus 8 (HHV-8) Genomes in US Blood Donors with Sensitive real-time PCR”

Astrid Van Halteren, MD, PhD
Leiden University Medical Center, Netherlands
“Pregnancy-Induced Minor Histocompatibility Alloimmune T Cells and Fetal Microchimerism: Friends of Foes?”

Kent W. Christopherson II, PhD
University of Texas Health Science Center, Houston
“CD26 Inhibition As A Method Of Improving Hematopoietic Stem Cell Transplant Efficiency”

Jeanne E. Hendrickson, MD
Emory University School of Medicine
“Effect Of Host Inflammation On Alloimmunization To RBC Transfusion”

Lana Kaiser MD, DVM
Michigan State University
“Transfusion Iron Overload And Cardiac Arrhythmias”

Marcus O. Muench, PhD
Blood Systems Research Institute
“In Utero Transplantation of The Hematopoietic Microenvironment”

Eric M. Ostertag, MD, PhD
University of Pennsylvania
“Cloning and Characterization of Monoclonal Anti-ADAMTS13 Autoantibodies from Patients with Thrombotic Thrombocytopenic Purpura (TTP)”

Robert Paulson, PhD
Penn State University
“Role Of BMP4 Signaling On Short-Term Radioprotection”

Jill Storry, PhD
Lund University, Sweden
“Characterization of the Vel Blood Group System”

Leon L. Su, MD
Emory University
“Recipient Kinetics and the Role of Host Factors in Transfusion-Transmitted Cytomegalovirus (TTCMV) Infection”

Lan Zhou, PhD
Case Western Reserve University
“Regulation of Granulopoiesis by Fucosylated Glycans Through Selectin-Mediated Adhesion and Fringe-Modified Notch Signaling Pathways”

Marie Bleakley, MD
Fred Hutchinson Cancer Research Center
“Discovery of Antigens for Targeted Therapy of Leukemia”

Jose Cancelas, MD, PhD
Cincinnati Children's Hospital Medical Center
“Mobilization of Hematopoietic Stem Cells by Reversible Inhibition of Rac-Type Rho GTPases: Demonstration of Proof-of-Concept for Future Clinical Applications”

Li Chai, MD
Brigham and Women's Hospital
“A Novel Intracellular Pathway of WT1/HSAL2 in Leukemogenesis”

Brian S. Custer, MPH, PhD
Blood Systems Research Institute
“Retrospective Cohort Analysis of Return Behavior in Temporarily Deferred and Eligible Voluntary Blood Donors”

Craig E. Daniels, MD
Mayo Clinic College of Medicine
“The Accuracy of Natriuretic Peptides (BNP and N-pro-BNP) in the Differentiation Between Transfusion Related Acute Lung Injury (TRALI) and Transfusion Related Circulatory Overload (TACO)”

Allison Hubel, MS, PhD
University of Minnesota
“Post Thaw Processing of Hematopoietic Stem Cell Products”

Andrew Mackin, BVMS, MVS, DVSc, FACVSc, Diplomate ACVIM
Mississippi State University
“Evaluation of the Efficacy of Phototreatment of Packed Red Blood Cells at Preventing Transfusion-Associated Transmission of Babesiosis In Dogs”

Nora Ratcliffe, MD
VAMC White River Junction and Manchester
“The Role of Dendritic Cell Subsets in Autoimmune Myocarditis and the Potential for Cytotherapy”

Steven R. Sloan, MD, PhD
Children's Hospital Boston
“Role of the CCL4 Chemokine in the Immune Response to Red Cell Transfusions: Implications for Immunosuppressive Therapy”

Ognjen Gajic, MD
Mayo Clinic
“Transfusion-Related Acute Lung Injury in the Medical Intensive Care Unit”

Andres Hidalgo, PhD
Mount Sinai School of Medicine
“Optimizing Cord Blood Transplantation by Upregulation of Selectin Ligands”

Qizhen Shi, MD, PhD
Medical College of Wisconsin
“Targeting Human Platelet Glycoprotein Ibα Gene Expression to the Platelets of Bernard-Soulier Syndrome Mice”

X. Long Zheng, MD, PhD
Children's Hospital of Philadelphia
“Characterization of Autoantibodies Directed Against ADAMTS13 Metalloprotease Underlying Thrombotic Thrombocytopenic Purpura”

James C. Zimring, MD, PhD
Emory University School of Medicine
“Selective Induction of Allotolerance in Bone Marrow Transplantation”

Laura Cooling, MD, MS
University of Michigan
“Molecular Analysis of Globo- and Lacto-Family Glycosyltransferases: Molecular Etiology of the LKE-Negative and LKE-Weak Phenotypes”

Yvonne H. Datta, MD
Medical College of Wisconsin
“Genetic Mapping and Characterization of the Bleeding Disorder in the Fawn-Hooded Hypertensive Rat”

Carl S. Goodyear, PhD
University of California San Diego
“Mechanisms of Immunomodulation by Protein A Pheresis”

Suresh Shelat, MD, PhD
University of Pennsylvania
“Characterization of the Human Immune Response in Heparin-Induced Thrombocytopenia Using Repetoire Cloning”

Steven L. Spitalnik, MD
Columbia University
“Hemolytic Transfusion Reactions: A Transgenic Mouse Model”

Scott S. Tykodi, MD, PhD
Fred Hutchinson Cancer Research Center
“Identification of Antigens Mediating Graft-versus-Tumor Effects Following MHC-Identical Allogeneic Hematopoietic Cell Transplantation”

Larry J. Dumont, MBA
Gambro BCT
“Human Cytomegalovirus (HCMV) Reactivation – Human Exposure Model and Mechanism D”

Michael Hodsdon, MD, PhD
Yale University
“Regulation of von Willebrand Factor Susceptibility to Proteolytic Cleavage by a Plasma Metalloproteinase”

Lennart Logdberg, MD, PhD
Emory University
“Use of Bone Marrow Stem Cells for Pancreatic Islet Repopulation and Regeneration”

Una O'Doherty, MD, PhD
University of Pennsylvania
“Regulation of HIV-1 Latency in Resting T Cells by Dendritic Cells”

Maria Bettinotti, PhD
National Institutes of Health
“Molecular Basis of Polymorphisms in Neturophil Antigen NB1: CD177”

Sandra L. Haberichter, PhD
Blood Research Institute; Blood Center of SE Wisconsin
“The Role of the von Willebrand Factor Propeptide in Targeting vWF to the Regulated Storage Pathway”

Jonathan David Kurtis, MD, PhD
Brown University
“Novel Erythrocyte Invasion Protiens As Vaccines For Human Falciparum Malaria”

Peter L. Perrotta, MD
SUNY @ Stony Brook
“Role Of Apoptotic Mechanisms In Platelet Dysfunction And Death”

Walter L. Biffl, MD
Denver Health Medical Center
“Blood Transfusion-Provoked Delay in Neutrophil Apoptosis in Trauma may be Altered by Modifying Transfusion Practices”

Jeffrey L. Carson, MD
UMDNJ-Robert Wood Johnson Medical School
“The Effect of Anemia and Transfusion on Postoperative Delirium”

Thomas H Fischer, PhD
University of North Carolina, Chapel Hill
“Hyperbaric Freezing for the Preparation of Rehydrated, Lyophilized Platelets”

James D. Gorham, MD, PhD
Dartmouth Medical School
“T Cell Cytokine Secretion in a Murine Model of Transfusion-associated ImmunoModulation (TRIM)”

Patricia Kopko, MD
Sacramento Medical Foundation Blood Centers
“The Association of HLA Class II Antibodies and White Blood Cell Activation with Transfusion-Related Acute Lung Injury”

Krista V. Lankford, MD
Emory University
“Mechanisms of Action of Therapeutic Plasma Exchange (TPE) in Thrombotic Metalloprotease (MP) and Its Antibody Inhibitor (IMP)”

Karina Yazdanbakhsh, PhD
New York Blood Center
“Recombinant Antigens as Tools for Identification of Alloantibodies in Patients' Sera”

David G. Meyers, MD
Kansas University Medical Center
“A Historical Cohort Study of the Effect of Lowering Body Iron Through Blood Donation on Cardiac Events”

Andrey Skripchenko, PhD
Holland Laboratory, American Red Cross
“The Mechanism(s) of virus Photoinactivation by Dimethylmethlene Blue”

Connie Westhoff, PhD
University of Pennsylvania
“Deciphering the Function of the Rh Proteins”

Douglas P. Blackall, MD
University of California, Los Angeles
“Recombinant Blood Group Antigen Engineering: Glycophorin A as a Model Glycoprotein”

Raymond L. Comenzo, MD
Boston Medical Center
“Immunoglobulin Genes And DNA Vaccines: Synergy With Stem-Cell Transplant?”

Robertson Davenport, MD
University of Michigan
“A Murine Model of Acute Hemolytic Transfusion Reactions”

Timothy C. Fisher, MB, Ch.B
USC School of Medicine
“Red Blood Cell Antigen Masking by Covalently-Bound Polyethylene Glycol”

Peter Larson, MD
University of North Carolina, Chapel Hill
“The Role of the GIA Domain in the Function of Vitamin K-dependent Coagulant Proteins”

Eleanor Pollack, MD
The Children's Hospital of Philadelphia
“Substrate and Inhibitor Binding Sites of Human Coagulation Factor Xa”

Jo Anna Reems, PhD
Blood Systems Foundation
“Ex Vivo Expansion of Human Umbilical Cord Blood Hematopoietic Progenitor Cells: Evaluation of their Function in a Mouse Transplant Model”

John Donald Roback, MD, PhD
Emory University Hospital
“The Role of Leukocytes in Transfusion-Transmitted Cytomegalovirus (TT-CMV) Infection: Development of an Animal Model”

John Rosenberg, PhD
Blood Center of Southeast Wisconsin
“Impact of von Willebrand Factor on Factor VIII Gene Targeting”

Scott Burger, MD
University of Minnesota, Minneapolis
"Adhesive Interactions in Hematopoietic Cell Homing"

Petr Jarolim, MD
Brigham and Women's Hospital
"Characterization of Blood Group Antigens Carried by Erythroid Band 3"

Diane Krause, MD, PhD
Yale University School of Medicine
"Regulation of Cd34 Expression During Hematopoiesis"

Stanley J. Naides, MD
University of Iowa
"Structure-Function Relations in Parvovirus B19 Binding to Solid Phase Immobilized Glyosphingolipid Cell Receptor"

Christopher Silliman, MD, PhD
Bonfils Blood Center
"The Pathophysiology of Transfusion Related Acute Lung Injury in an Animal Model and In Vitro Investigation of Endothelium as an Active Participant"

Emily Baron-Casella, PhD
The Johns Hopkins University School of Medicine
"Identification of the Epitopes and Antibodies Involved in the HPA-3 (Bak) and HPA-4 (Pen) Alloantigen Systems"

Tylis Y. Chang, MD
University of Pennsylvania
"ABO Antibodies: The Ontogeny of the "Natural Repertoire"

Laura Cooling, MD
University of Iowa
"Population Differences in Blood Group Antigen Expression Among Normal Platelet Donors"

Loren D. Fast, PhD
Rhode Island Hospital
"The Immunological Consequences of Blood Transfusion: Early Events"

Karen E. King, MD
The Johns Hopkins Hospital
"The Role of Complement and Complement Inhibitors in Delayed Hemolytic Transfusion Reactions"

Louis V. Kirchhoff, MD
University of Iowa
"Use of Recombinant Trypanosoma Cruzi Proteins for Serologic Diagnosis of Chagas Disease"

Joni M. Lohmann, MD
Veterans Affairs, Medical Center
"Nonisotopic Analysis of the Survival Characteristics of Multiple Concurrent Platelet Populations with a Biotin Label"

Jack T. Stapleton, MD
University of Iowa
"Detection of Hepatitis C Virus RNA in the Whole Blood of Volunteer Blood Donors with and Without Elevated Alanine Transanimase"

Neil Young, Msc, FIBMS
University of Oxford, England
"Molecular Analysis of Alloreactivity in Recipients of HLA-One-Haplotype-Matched or Fully HLA-Mismatched Pre-Transplant Blood Transfusions"

Francesco Bertolini, MD, PhD
Maugeri Foundation, Pavia Medical Center, Italy
"Collection and Ex-Vivo Expansion of Placental Blood-Derived Hematopoietic Progenitors for Transplantation"

Brian Curtis, BS, MT(ASCP)SBB
The Blood Center of Southeastern Wisconsin
"Role of ABO Blood Group Incompatibility in the Pathogenesis of Neonatal Alloimmune Thrombocytopenic Purpura"

Louis A. DePalma, MD
The George Washington University Medical Center
"Gene Expression in Activated Cord Lymphocytes: Relevance to Neonatal Immunohematology"

Susan H. Eshleman, MD, PhD
Case Western Reserve University
"Regulation of Protein Glycosylation: Characterization of Glycosylation Signals for Recombinant Protein Design"

Malcolm R. MacKenzie, MD
Sacramento Medical Foundation Center for Blood Research
"Immunoregulatory B Cells in Transfusion"

Martha Osborne
Central Kentucky Blood Center
"Retaining First Time Donors: Testing the Effectiveness of Interventions Designed to Increase Personal Perception as a Committed Donor"

Robert I. Roth, MD, PhD
Department of Veterans Affairs Medical Center
"A Mechanism for Endothelial Cell-mediated Thrombosis: Deleterious Consequences of the Interaction of Cell-free Hemoglobin and Bacterial Endotoxin"

Gerald Soslau, PhD
Hahnemann University
"Response of Stored Platelets to Paired Agonists in the Presence and Absence of Extracellular ATP"

Connie Westhoff, PhD
University of Nebraska, Lincoln
"Targeted Deletion of the Rh Genes in Human Erythroleukemia Cells"

Theodore Wun, MD
University of California Davis Cancer Center
"Thrombopoietin Effects on Human Platelets"

Douglas P. Blackall, MD
University of Tennessee
"Human Blood Group Glycophorins as Receptors for the Plasmodium falciparum Malaria Parasite"

Paul F. Bray, MD
The Johns Hopkins University School of Medicine
"Application of Novel Molecular Methods to Genotype and Identify New Platelet Specific Antigens"

Umakant J. Dumaswala, PhD
Hoxworth Blood Center
"Glutamine Improves Red Cell Preservation"

Walter H. Dzik, MD
New England Deaconess Hospital
"Transient Microchimerism Following Allogeneic Blood Transfusion"

Cheng-Han Huang, MD, PhD
New York Blood Center
"Studies on Human S-s-U and S-s-U+ Red Blood Cells–Molecular Basis, Phenotypic Heterogeneity and Relationship to Other Surface Markers of Glycophorin"

Maryanne Keashen-Schnell
American Red Cross Blood Services
"Antibody Detection in the Thrombocytopenic Disorders of Pregnancy"

Alan H. Lazarus, PhD
St. Michael's Hospital, Canada
"Study of a B-cell Regulatory Pathway to Delay or Prevent Platelet Alloimmunization in a Human-PBMC-SCID Mouse Model"

Christine S. Rinder, MD
Yale University School of Medicine
"An In Vitro Model of the Effects of Platelet Transfusion on Leukocyte Function"

S.M. Hossein Sadrzadeh, PhD
New England Deaconess Hospital
"Oxygen Free Radical Damage of Gamma-Irradiated Blood"

Jeffrey L. Carson, MD
UMDNJ – Robert Wood Johnson Medical School
"Cost Effectiveness of Autologous Blood Transfusion"

Scott Cobourn, PhD
Duke University Medical Center
"Regulation of CD44 Expression in Erythroid Cells"

Ellen P. Klohe, PhD
Inland Northwest Blood Center
"Effects of Methyldopa on Leukocyte Subpopulations"

Douglas M. Lublin, MD, PhD
Washington University School of Medicine
"Molecular Genetic Analysis of Rh Blood Group System"

Marion Reid, PhD
New York Blood Center
"Studies on the Surface Markets of Glycophorin in Molecules in Human Red Blood Cells"

Rosetta Sue Shirey, MS, MT(ASCP)SBB
The Johns Hopkins Hospital
"An Animal Model of DSTR and DHTR"

Michael P. Busch, MD, PhD
Irwin Memorial Blood Centers
"Impact of Homologous Blood Transfusion on HIV Replication and Disease in Vivo"

Loren D. Fast, PhD
Rhode Island Hospital
"Blood Transfusion and GVHD: Induction, Prevention and Modulation"

Linda L. Kelley, PhD
Vanderbilt University
"Erythropoietin Regulation of the Cell Cycle in Erythroid Progenitor Cells"

Stuart E. Lind, MD
Brigham and Women's Hospital
"Use of Conjugated Estrogens in Von Willebrand's Disease"

Joann Moulds, PhD
University of Texas Medical School
"Determination and Localization of Human Blood Group Polymorphisms on Complement Receptor One (CR1)"

Raymond L. Comenzo, MD
Tufts Medical Center
"On the Role of Fibronection in Peripheral Blood Progenitor Cell Amplification"

Christopher D. Hillyer, MD
Emory University Hospital Blood Bank
"Peripheral Blood Stem Cells for Allogeneic Transplantation: Development of an Animal Model-Initial Phase Investigations"

Hwai-Tai C. Lam, MS, MT(ASCP)SBB
University of California, Los Angeles
"A Cost-Effective Study of a Prospective Utilization Monitoring Program for Transfusion Practice"

Peter J. Larson, MD
University of North Carolina, Chapel Hill
"The Role of the GIA Domain in the Function of Vitamin K-dependent Coagulant Proteins"

John B. Lowe, MD
University of Michigan, Ann Arbor
"Molecular Genetics of the Human Lewis and Lewis-related Blood Group Loci"

Donald L. Siegel, PhD, MD
Hospital of the University of Pennsylvania
"Biology of Human Warm Autoimmune Hemolytic Anemia"

Kenneth D. Friedman, MD
University of New Mexico, Albuquerque
"Studies of von Willebrand Variants to Define the VWF Domain that Binds Glycoprotein IB"

Douglas M. Lublin, MD, PhD
Washington University
"Molecular Biological Approaches to Immunohematology: Pilot Study of Cromer Blood Group"

Allen Mayer, MD, PhD
Irwin Memorial Blood Center
"Adaptation of Capillary Separation to PCR Amplification for Donor Infectious Disease Screening"

C. Ann Rearden, MD
University of California, San Diego
"Antigenicity and Autogenicity of the MN Blood Group Sialoglycoprotein Glycophorin A"

Brian R. Smith, MD
Yale University School of Medicine
"Platelet-Leukocyte Interactions"

Douglas M. Smith, MD
University of Nebraska Medical Center
"Allogeneic Peripheral Blood Stem Cell Transplantation in Yucatan Miniature Swine"

Neil Blumberg, MD
University of Rochester Medical Center
"Comparison of the Clinical and Immunologic Effects of Autologous or Homologous Blood Transfusions in Patients Undergoing Spinal Fusion Surgery"

Janice P. Dutcher, MD
Montefiore Medical Center
"Evaluation of Hematologic Changes Associated with Interlukin-2 Administration to Patients with Metastatic Malignancy and Evaluation of Migration of Activated Autologous Lymphocytes in these Patients"

Walter H. Dzik, MD
New England Deaconess Hospital
"Leukopoor Platelet Concentrates: Development and Evaluation of a Method for Preparing Leukocyte Depleted Platelet Concentrates from Single Units of Whole Blood"

Joseph P. Meyer/John A. Barrett, MD
Cook County Hospital
"Fresh Frozen Plasma Use During Massive Transfusion"

Sandra J. Nance, MS, MT(ASCP)SBB
American Red Cross, Los Angeles-Orange Counties Region
"A Comparison of the Efficiency of the Monocyte Monolayer Assay IgG Subclassing, OD450 Amniotic Fluid, and Ultrasonography in Prediction of the Severity of Hemolytic Disease of the New Born"

James A. Sloand, MD
Highland Hospital
"Characterization of Platelet Glycoprotein Ib in Chronic Renal Failure"

Timothy H. Carlson, PhD
University of New Mexico, Albuquerque
"Preparation and Properties of an Improved Antithrombin III Concentrate"

Thomas S. Kickler, MD
The Johns Hopkins Hospital
"Antiallotypic Antibodies in Platelet Transfusion Recipients–Their Clinical Significance"

Joann Moulds, MS, MT(ASCP)SBB
University of Texas, Houston
"Quantitation of C4A (Rodgers) and C4B (Chido) in Order to Study Their Role in Complement Mediated Pathology"

Harry E. Prince, PhD
American Red Cross, Los Angeles-Orange Counties Region
"Lymphocyte Activation by Oxidized Erythrocytes: Characterization of the Responding Cells and the Cellular Interactions Required"

Chester Andrzejewski, PhD, MD
University Intramural Correspondence
"New Assessments of Anti-Erythrocyte Autoantibody Heterogeneity in Immune Hemolytic States"

Jerome L. Gottschall, MD
The Blood Center of Southeastern Wisconsin
"Mechanism of Action of Platelet Aggregating Factor in TTP: Implications for Gamma Globulin Therapy"

Lauralynn Lebeck, MT(ASCP)SBB
St. Luke's Medical Center
"Immunoregulatory Activity of Human Bone Marrow Mononuclear Cells."

John B. Lowe, MD
Howard Hughes Medical Institute
"The Molecular Biology of the Human A Blood Group Glycosyltransferases"

Paul Mintz, MD
University of Virginia Medical Center
"Correlation of Non-invasive Assessment of Platelet Morphology with Platelet Recovery and Survival"

David Scrivner, MD
American Red Cross, St. Louis Bi-State Chapter
"Hydrocortisone Impairs Lak Activity by Inhibition of Effector/Target Cell Binding"

Edward L. Snyder, MD
Yale University School of Medicine
"Calcium-Dependent Proeolysis of Actin During Storage of Platelet Concentrates"

Edward J. Victoria, PhD
University of California, San Diego
"Transmembrane Skeletal Association of the RH Antigens."

James P. AuBuchon, MD
American Red Cross, Rochester Region
"Use of Indium111 as a Red Cell Label in Survival Studies"

Brooks Jackson, MD
University of Minnesota Hospitals
"Non-Detection of Human Cytomegalovirus DNA in IgM Seropositive Blood Donor Using Spot Hybridization"

Melanie S. Kennedy
Ohio State University Hospitals
"Managerial Role Delineation for Blood Bank Specialists"

Jane M. Rachel, MT(ASCP), MA
Community Blood Center of Greater Kansas City
"Evaluation of a Solid Phase Red Cell Adherence Method for Prospective Platelet Crossmatching"