Preparative Apheresis and Transfusion Support for Sickle Cell Disease Gene Therapy (25EL-527)

Please note: AABB reserves the right to make updates to this program.

• Educational Track: Technical/Clinical
• Topics: Blood Donation & Collection, Patient Transfusion
• Intended Audience: Hospitals, Immunohematology Reference Labs (IRL’s), Laboratory Staff, Managers/Supervisors, Medical Directors, Nurses, Physicians, Research Scientists, Residents/Fellows, Scientists, Students (MD, MT, SBB), Technologists, Transfusion Safety Officers
• Teaching Level: Advanced, Intermediate

• Director/Moderator: Elizabeth St. Lezin, MD, Clinical Professor of Laboratory Medicine Emeritus, UCSF, San Francisco, CA
  Speaker: John Manis, MD, Associate Professor Pathology, Harvard Medical School & Boston Children’s Hospital, Boston, MA

• Program Description

  For many patients with sickle cell disease (SCD), hematopoietic stem cell transplantation is unavailable due to lack of a matched donor. Gene therapy using autologous gene-edited stem cells has emerged as an option for these patients. Two gene therapy regimens have been approved by the FDA and additional clinical trials are underway. This program will provide background on gene therapy for SCD and an update on the status of SCD gene-editing clinical trials. The program will also address challenges in preparing products for patients enrolled in these trials and for the transfusion services providing transfusion support.

  Learning Objectives

  After participating in this educational activity, participants should be able to:

  • Demonstrate understanding of the role of gene therapy and gene-editing in the treatment of SCD.
  • Identify current FDA-approved gene therapy regimens and key gene-editing clinical trials in SCD.
  • Apply understanding of preparative transfusions for mobilization and collection of stem cells for SCD cell therapies.

  Registration

  Registration includes access to both the live and on-demand version of this eCast.

  If you are a facility interested in participating in this eCast, simply complete the Group Viewing registration form and AABB will provide detailed instructions to share with your team approximately one week prior to the live program (each team member to register for the program utilizing a promocode). For single viewers, simply click on the Register button below to register.

  Please note: registration for the live eCast will close 1 hour prior to the eCast start time. If you register after this time, you will receive access to the on-demand eCast when it is available.

  Single Viewer	Register
  Group Viewing	Register

  Continuing Education Credit

  This activity is eligible for one (1) continuing education credit/contact hour for Physicians, Nurses (including California-based nursing professionals through CBRN), California Lab Personnel, Florida Lab Personnel and General Participation credit. AABB reserves the right to reduce or increase the number of credits granted based on the final activity duration. For more information on each credit type please visit our Continuing Education Credits webpage.

  There is no financial support for this activity.

  

  In support of improving patient care, this activity has been planned and implemented by the Association for the Advancement of Blood & Biotherapies (AABB) and CME Outfitters, LLC. CME Outfitters LLC. is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

  Physicians (ACCME): CME Outfitters, LLC, designates this live activity for a maximum of one (1) AMA PRA Category 1 Credit^TM. CME Outfitters, LLC, designates this enduring activity for a maximum of one (1) AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  Claiming Credit
  Live Activity - Upon completion of the live activity, you will receive instructions to complete your evaluation, which is necessary to claim credit and receive your certificate of attendance/completion (credit must be claimed by the date provided in the instructions). The evaluation can be found by logging into the AABB Education Platform.

  Enduring Activity - Once the enduring (on-demand) program is available, you will receive instructions to access the AABB Education Platform. Upon completion of viewing the enduring activity, you will need to complete the evaluation, which is necessary to claim credit and receive your certificate of completion (credit must be claimed by the date provided in the AABB Education Platform).

  Program & Credit Expiration Dates:

  • Live Activity Program Date: April 23, 2025; Credit Expiration Date: May 23, 2025
  • Enduring Activity Program Dates: April 23, 2025 – April 22, 2028; Credit Expiration Date: April 22, 2028

  Disclosure Declaration

  It is the policy of CME Outfitters, LLC, and the Association for the Advancement of Blood & Biotherapies to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that the presence of such relationships will have a negative impact on the presentations.

  Disclosures for the planners of this event can be found here. Disclosures for the program faculty, peer reviewers, and CME Outfitters, LLC. personnel are provided at the beginning of the program.

  Faculty Biographies

  Dr. John Manis is an Associate Professor of Pathology at Harvard Medical School & Boston Children’s Hospital located in Boston, MA

  
  

  Dr. Elizabeth (Beth) St. Lezin is a Professor of Laboratory Medicine, Assistant Chief Laboratory Medicine and Director of Transfusion Service at the University of California San Francisco. Her research and clinical interests include clinical transfusion medicine, health and quality of life outcomes in red cell transfusion recipients, laboratory management and quality improvement in the clinical laboratory, and genetics of complex cardiovascular traits. Dr. St. Lezin has been the recipient of multiple awards including: Sudikow Award for Quality Improvement, UCSF/Mt. Zion Medical Center 1998; Laboratory Medicine Faculty Teaching Award 2016; and UCSF Center for Faculty Educators Certificate in Clinical Teaching 2018.