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Standards for Immunohematology Reference Laboratories

Outlines requirements for highly specialized laboratories that provide an essential service to patients who have specific serologic complexities and/or need rare blood components.

Current edition: 13th edition
Effective date: April 1, 2024
Revision cycle: 24 months (April of even numbered years)


Purchase Standards

Acquiring Standards

The print version, Portal versions, printed guidance and bundle packages of the 12th edition of Standards for Immunohematology Reference Laboratories, are available for purchase.

Note: The print version, portal version, printed guidance and bundle packages of the 13th edition of Standards for Immunohematology Reference Laboratories are available for purchase, however will not take effect until April 1, 2024.

Standards Development

  • Immunohematology Reference Laboratories – Inventory Resources, Reference Standards 2.2.A and B.
  • Response to Comments Received to the 10th edition of Standards for Immunohematology Reference Laboratories.
  • Response to Comments Received to the 11th edition of Standards for Immunohematology Reference Laboratories.
  • Significant Changes and Response to Comments to the 12th edition of Standards for Immunohematology Reference Laboratories.

Accreditation Activities

AABB uses the standards described in Standards for Immunohematology Reference Laboratories as a basis for accrediting laboratories for advanced serology testing and reference lab services equipped for performing advanced investigational procedures pertaining to immunohematologic studies.

Immunohematology Reference Laboratories provide an exchange of information and consultation on rare blood group antibodies, grouping, component preparation and therapy, blood compatibility testing and research.


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