Immunohematology Boot Camp: Duffy System (25EL-509)

Please note: AABB reserves the right to make updates to this program.

• Educational Track: Technical/Clinical
• Topics: Blood Donation & Collection, Patient Transfusion
• Intended Audience: Immunohematology Reference Labs (IRL’s), Laboratory Staff, Managers/Supervisors, Medical Directors, Physicians, Residents/Fellows, Students (MD, MT, SBB), Technologists
• Teaching Level: Advanced, Basic, Intermediate

• Director/Moderator: Elizabeth P. Crowe, MD, PhD, Assistant Professor, Department of Pathology, Division of Transfusion Medicine, Johns Hopkins University School of Medicine; Medical Director, Blood Bank, Johns Hopkins Hospital, Baltimore, MD
  Speaker:

  • Kathy Haddaway, MLS(ASCP)^CMSBB^CM, Technical Specialist II - Transfusion Medicine Division, Johns Hopkins Hospital, Baltimore, MD

• Program Description

  This program explores the Duffy (FY) blood group system antigens and related antibodies using a lecture format with accompanying complex serologic case studies. Beginning with an overview of the structure and physiologic role of the FY glycoprotein, ACKR1 (Atypical Chemokine Receptor 1), this program will describe the significance of this glycoprotein as a ligand for malarial parasites and the effect on natural selection for the Fy(a-b-) phenotype. The molecular basis of FY blood system antigens along with genetic variations that affect FY blood group system antigen expression will be described. Furthermore, the link between Fy(a-b-) red blood cell phenotype and Duffy-null Associated Neutrophil Count (DANC) will be examined highlighting the critical role of the transfusion service laboratory in confirming the diagnosis to ensure appropriate clinical management. Finally, this program will review the clinical significance of antibodies directed against FY blood group system antigens and utilize case studies to illustrate approaches to identify these antibodies in the transfusion service laboratory.

  Learning Objectives

  After participating in this educational activity, participants should be able to:

  • Describe the function of the FY Glycoprotein, ACKR1 and its role in malarial infections.
  • Explain the molecular basis of the Fy(a-b-) phenotype.
  • Define Duffy-null Associated Neutrophil Count (DANC) and its implications in clinical practice.
  • Discuss the clinical significance of antibody formation to the Duffy antigens.
  • Interpret complex serologic case studies using characteristics of antibodies in the Duffy system.

  Registration

  Registration includes access to both the live and on-demand version of this eCast.

  If you are a facility interested in participating in this eCast, simply complete the Group Viewing registration form and AABB will provide detailed instructions to share with your team approximately one week prior to the live program (each team member to register for the program utilizing a promocode). For single viewers, simply click on the Register button below to register.

  Please note: registration for the live eCast will close 1 hour prior to the eCast start time. If you register after this time, you will receive access to the on-demand eCast when it is available.

  Single Viewer	Register
  Group Viewing	Register

  Continuing Education Credit

  This activity is eligible for one (1) continuing education credit/contact hour for Physicians, Nurses (including California-based nursing professionals through CBRN), California Lab Personnel, Florida Lab Personnel and General Participation credit. AABB reserves the right to reduce or increase the number of credits granted based on the final activity duration. For more information on each credit type please visit our Continuing Education Credits webpage.

  There is no financial support for this activity.

  

  In support of improving patient care, this activity has been planned and implemented by the Association for the Advancement of Blood & Biotherapies (AABB) and CME Outfitters, LLC. CME Outfitters LLC. is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

  Physicians (ACCME): CME Outfitters, LLC, designates this live activity for a maximum of one (1) AMA PRA Category 1 Credit^TM. CME Outfitters, LLC, designates this enduring activity for a maximum of one (1) AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  Claiming Credit
  Live Activity - Upon completion of the live activity, you will receive instructions to complete your evaluation, which is necessary to claim credit and receive your certificate of attendance/completion (credit must be claimed by the date provided in the instructions). The evaluation can be found by logging into the AABB Education Platform.

  Enduring Activity - Once the enduring (on-demand) program is available, you will receive instructions to access the AABB Education Platform. Upon completion of viewing the enduring activity, you will need to complete the evaluation, which is necessary to claim credit and receive your certificate of completion (credit must be claimed by the date provided in the AABB Education Platform).

  Program & Credit Expiration Dates:

  • Live Activity Program Date: February 26, 2025; Credit Expiration Date: March 26, 2025
  • Enduring Activity Program Dates: February 26, 2025 – February 25, 2028; Credit Expiration Date: February 25, 2028

  Disclosure Declaration

  It is the policy of CME Outfitters, LLC, and the Association for the Advancement of Blood & Biotherapies to ensure independence, balance, objectivity, and scientific rigor and integrity in all of their CE activities. Faculty must disclose to the participants any relationships with commercial companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. CME Outfitters, LLC, has evaluated, identified, and mitigated any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that the presence of such relationships will have a negative impact on the presentations.

  Disclosures for the planners of this event can be found here. Disclosures for the program faculty, peer reviewers, and CME Outfitters, LLC. personnel are provided at the beginning of the program.

  Faculty Biographies

  Dr. Elizabeth (Liz) Crowe is an Assistant Professor in the Department of Pathology at the Johns Hopkins University School of Medicine. She is also the Medical Director of the blood bank and the Specialist in Blood Bank Technology/Transfusion Medicine (SBBT/TM) at the Johns Hopkins Hospital. Her areas of interest include transfusion medicine education, patient blood management and immunohematology.

  
  

  Kathy Haddaway is the Technical Specialist II for the Transfusion Medicine Laboratory and the Education Coordinator for the Specialist in Blood Bank Technology/Transfusion Medicine (SBBT/TM) program at the Johns Hopkins Hospital. She oversees the specialized immunohematology testing performed in the Transfusion Medicine laboratory and works closely with physicians to ensure appropriate patient testing and transfusion. Her interests include transfusion medicine education and use of molecular methods to resolve complex immunohematology cases, especially in the Rh system.